Fecha/hora: 20/05/2024 14:06:49

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	26/01/2024	
Fecha de la última actualización: 	26/01/2024	
Autoria: 	BRANDA-SICA, A.; ARTIGAS, R.; DE TORRES, E.; KINLEY, E.; NICOLINI, P.; FEDERICI, M.; LLAMBÍ, S.	
Afiliación: 	ANDREA BRANDA SICA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RODY ARTIGAS, Facultad de Veterinaria, Unidad Académica de Genética y Mejora Animal, Universidad de la República, Montevideo, Uruguay; ELENA DE TORRES, Facultad de Veterinaria, Campo Experimental N°2, Universidad de la República, San José, Uruguay; EVANGELINA KINLEY, Facultad de Veterinaria, Campo Experimental N°2, Universidad de la República, San José, Uruguay; PAULA NICOLINI, Centro Universitario de Tacuarembó, Instituto Superior de la Carne, Universidad de la República, Tacuarembó, Uruguay; MARIA TERESA FEDERICI RODRIGUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SILVIA LLAMBÍ, Facultad de Veterinaria, Unidad Académica de Genética y Mejora Animal, Universidad de la República, Montevideo, Uruguay.	
Título: 	Monitoring of recessive defects associated with low reproductive performance in dairy cattle in Uruguay.	
Año de publicación: 	2023	
Fuente/Imprenta: 	Open Veterinary Journal, 2023, Volume 13, Issue 10, Pages 1290-1298.  http://doi.org/10.5455/OVJ.2023.v13.i10.8  -- OPEN ACCESS.	
ISSN: 	2226-4485	
DOI: 	10.5455/OVJ.2023.v13.i10.8	
Idioma: 	Inglés	
Notas: 	Article history: Submitted: 02 July 2023, Accepted: 12 September 2023, Published: 31 October 2023. -- Document type: Article Gold Open Access, Article Green Open Access. -- Correspondence: Branda-Sica, A.; Instituto Nacional de Investigación Agropecuaria, Sistema Ganadero Extensivo-Salud Animal, Canelones, Uruguay; email:abranda@inia.org.uy  -- Funding: The research leading to the results presented in this publication received funding from ANII (POS_ NAC_2017_1_141239), INIA (projects PL_027 N-23398 and BT_21 N-23330), and CSIC-UdelaR. -- Data availability_ The data supporting the findings of this study are available within the manuscript. Any other data are available from the corresponding author upon reasonable request. --	
Contenido: 	ABSTRACT.- Background: Most dairy cattle breeds originate show an average generational inbreeding rate of 1%, which favors the occurrence of recessive defects associated with low reproductive performance. Aim: The objective of this study was to monitor recessive defects associated with low reproductive performance in dairy cattle. Methods: To monitor bulls carrying the Holstein Friesian haplotype (HH) 1, HH3, and HH4 haplotypes, we analyzed the records of 3,028 national and imported Holstein Friesian bulls from the 2021 updated sires' catalog published by "Evaluaciones Genéticas Lecheras"; and to determine the presence of these mentioned haplotypes, as well as Jersey haplotype (JH) 1 and complex vertebral malformation (CVM), were genotype with the GeneTitan® 2,500 single nucleotide polymorphism (SNP) bovine chip, estimate their frequencies and evaluate their impact on the fertility of 100 Holstein Friesian cows and 70 Holstein Friesian-Jersey crosses belonging to an experimental dairy. Results: From a total of 1,468 (48.5%) bulls with genetic information from the sires' catalog for HH1 and 1,471 (48.6%) for HH3 and HH4, we found 90 (6.1%) carriers for HH1, 60 (4.1%) for HH3, and 6 (0.4%) for HH4, respectively. By genotyping with the chip, we calculated the herd frequency of the mutant alleles and herd prevalence of carriers for HH1 and CVM as q = 0.003 and 0.022; 0.59% and 4.3% (call rate >0.99), respectively. No mutant alleles were found for HH3, HH4, and JH1 in the analyzed population. We examined reproductive data by observing the presence of CVM and HH1 mutant alleles in repeat cows with an average of four services to achieve pregnancy. Conclusion: This study demonstrated the presence of recessive defects associated with low reproductive performance in the analyzed population, which can affect the health and productivity of dairy cattle. Therefore, cows and bulls should be closely monitored through genetic testing to lower the incidence of recessive defects in dairy cattle. © 2023, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.	
Palabras-Clave: 	Artificial insemination; Bos taurus; Fertility; Hereditary diseases; Partnership for the goals - Goal 17; SISTEMA GANADERO EXTENSIVO - INIA; Sustainable Development Goals (SDGs).	
Categoría del tema: 	L10 Genética y mejoramiento animal	
URL: 	https://www.openveterinaryjournal.com/fulltext/100-1688127919.pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103785-1) - PXI - AP - DD - PP/Open Veterinary Journal/2023 -  -  - DIS